Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
drd2_human | 272 | ICL3 | A => Ter | stop gained | 3.569e-05 | 4 | 112082 | 0 | None | None | ||
drd2_human | 443 | C-term | C => F | missense | 8.238e-06 | 1 | 121396 | 0 | 0.0 | 1.0 | ||
drd2_human | 442 | 8.59x59 | H8 | H => Y | missense | 8.238e-05 | 10 | 121394 | 0 | 0.13 | 0.998 | |
drd2_human | 431 | 8.48x48 | H8 | I => T | missense | 5.766e-05 | 7 | 121406 | 0 | 0.25 | 0.067 | GP (contact) |
drd2_human | 410 | 7.37x36 | TM7 | A => T | missense | 0.001046 | 127 | 121392 | 1 | 0.04 | 0.219 | LB (hydrophobic, Van der Waals) |
drd2_human | 410 | 7.37x36 | TM7 | A => S | missense | 8.238e-06 | 1 | 121392 | 0 | 0.0 | 0.714 | LB (hydrophobic, Van der Waals) |
drd2_human | 404 | 7.31x30 | TM7 | P => R | missense | 8.241e-06 | 1 | 121346 | 0 | 0.0 | 0.975 | |
drd2_human | 399 | 6.61x61 | TM6 | C => R | missense | 8.252e-06 | 1 | 121180 | 0 | 0.0 | 0.999 | |
drd2_human | 389 | 6.51x51 | TM6 | F => V | missense | 8.343e-06 | 1 | 119862 | 0 | 0.0 | 1.0 | LB (hydrophobic, Van der Waals, polar (hydrogen bond)) |
drd2_human | 381 | 6.43x43 | TM6 | V => M | missense | 3.401e-05 | 4 | 117612 | 0 | 0.0 | 0.917 | |
drd2_human | 377 | 6.39x39 | TM6 | I => T | missense | 8.25e-06 | 1 | 121214 | 0 | 0.0 | 0.996 | |
drd2_human | 376 | 6.38x38 | TM6 | A => T | missense | 8.246e-06 | 1 | 121278 | 0 | 0.02 | 0.997 | |
drd2_human | 366 | 6.28x28 | TM6 | Q => K | missense | 8.238e-06 | 1 | 121384 | 0 | 0.87 | 0.779 | GP (contact) |
drd2_human | 360 | ICL3 | R => H | missense | 0.000173 | 21 | 121404 | 0 | 0.02 | 0.927 | ||
drd2_human | 360 | ICL3 | R => C | missense | 8.237e-06 | 1 | 121404 | 0 | 0.0 | 0.949 | ||
drd2_human | 356 | ICL3 | K => R | missense | 8.237e-06 | 1 | 121404 | 0 | 0.21 | 0.938 | ||
drd2_human | 354 | ICL3 | S => C | missense | 8.237e-06 | 1 | 121408 | 0 | 0.0 | 0.839 | PTM (Phosphorylation) | |
drd2_human | 352 | ICL3 | R => Q | missense | 2.471e-05 | 3 | 121406 | 0 | 0.38 | 0.052 | ||
drd2_human | 352 | ICL3 | R => W | missense | 3.295e-05 | 4 | 121406 | 0 | 0.06 | 0.921 | ||
drd2_human | 348 | ICL3 | N => S | missense | 3.295e-05 | 4 | 121408 | 0 | 0.03 | 0.487 | ||
drd2_human | 340 | ICL3 | I => T | missense | 8.237e-06 | 1 | 121404 | 0 | 0.42 | 0.003 | ||
drd2_human | 334 | ICL3 | H => Q | missense | 8.237e-06 | 1 | 121410 | 0 | 0.49 | 0.137 | ||
drd2_human | 331 | ICL3 | A => V | missense | 8.237e-06 | 1 | 121408 | 0 | 0.14 | 0.373 | ||
drd2_human | 329 | ICL3 | G => R | missense | 8.237e-06 | 1 | 121402 | 0 | 0.2 | 0.997 | ||
drd2_human | 327 | ICL3 | K => E | missense | 0.003814 | 463 | 121404 | 4 | 0.43 | 0.281 | ||
drd2_human | 323 | ICL3 | A => T | missense | 1.648e-05 | 2 | 121392 | 0 | 0.56 | 0.005 | ||
drd2_human | 314 | ICL3 | G => D | missense | 8.24e-06 | 1 | 121366 | 0 | 0.53 | 0.148 | ||
drd2_human | 314 | ICL3 | G => S | missense | 1.648e-05 | 2 | 121368 | 0 | 0.8 | 0.004 | ||
drd2_human | 311 | ICL3 | S => C | missense | 0.02641 | 3202 | 121226 | 73 | 0.03 | 0.999 | ||
drd2_human | 310 | ICL3 | P => L | missense | 3.3e-05 | 4 | 121218 | 0 | 0.28 | 0.016 | ||
drd2_human | 310 | ICL3 | P => S | missense | 0.001369 | 166 | 121220 | 2 | 0.74 | 0.004 | ||
drd2_human | 309 | ICL3 | D => N | missense | 0.0001155 | 14 | 121192 | 0 | 0.48 | 0.002 | ||
drd2_human | 300 | ICL3 | P => H | missense | 8.271e-06 | 1 | 120900 | 0 | 0.06 | 0.853 | ||
drd2_human | 294 | ICL3 | R => Q | missense | 8.333e-06 | 1 | 120008 | 0 | 0.42 | 0.075 | ||
drd2_human | 294 | ICL3 | R => W | missense | 8.332e-06 | 1 | 120024 | 0 | 0.01 | 0.849 | ||
drd2_human | 291 | ICL3 | E => A | missense | 8.34e-06 | 1 | 119910 | 0 | 0.1 | 0.775 | ||
drd2_human | 291 | ICL3 | E => K | missense | 2.503e-05 | 3 | 119844 | 0 | 0.37 | 0.786 | ||
drd2_human | 288 | ICL3 | S => T | missense | 8.366e-06 | 1 | 119532 | 0 | 0.43 | 0.105 | ||
drd2_human | 287 | ICL3 | T => I | missense | 8.374e-06 | 1 | 119424 | 0 | 0.26 | 0.595 | ||
drd2_human | 282 | ICL3 | E => D | missense | 1.692e-05 | 2 | 118174 | 0 | 0.45 | 0.021 | ||
drd2_human | 279 | ICL3 | L => Q | missense | 8.585e-06 | 1 | 116488 | 0 | 0.19 | 0.622 | ||
drd2_human | 276 | ICL3 | A => T | missense | 8.887e-06 | 1 | 112520 | 0 | 0.28 | 0.117 | ||
drd2_human | 275 | ICL3 | R => Q | missense | 8.998e-06 | 1 | 111130 | 0 | 0.55 | 0.028 | ||
drd2_human | 274 | ICL3 | R => Q | missense | 2.733e-05 | 3 | 109766 | 0 | 0.59 | 0.309 | ||
drd2_human | 269 | ICL3 | R => K | missense | 8.236e-06 | 1 | 121412 | 0 | 1.0 | 0.001 | ||
drd2_human | 268 | ICL3 | R => Q | missense | 2.471e-05 | 3 | 121412 | 0 | 0.28 | 0.396 | ||
drd2_human | 268 | ICL3 | R => W | missense | 1.647e-05 | 2 | 121412 | 0 | 0.01 | 0.95 | ||
drd2_human | 256 | ICL3 | I => V | missense | 8.236e-06 | 1 | 121412 | 0 | 0.38 | 0.275 | ||
drd2_human | 255 | ICL3 | V => I | missense | 8.236e-06 | 1 | 121412 | 0 | 0.47 | 0.39 | ||
drd2_human | 250 | ICL3 | M => V | missense | 1.647e-05 | 2 | 121412 | 0 | 1.0 | 0.001 | ||
drd2_human | 246 | ICL3 | H => Y | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.995 | ||
drd2_human | 234 | ICL3 | A => T | missense | 8.326e-06 | 1 | 120110 | 0 | 0.45 | 0.008 | ||
drd2_human | 230 | ICL3 | R => Q | missense | 8.282e-06 | 1 | 120746 | 0 | 1.0 | 0.015 | ||
drd2_human | 227 | ICL3 | R => H | missense | 1.651e-05 | 2 | 121114 | 0 | 0.03 | 0.982 | ||
drd2_human | 227 | ICL3 | R => G | missense | 7.427e-05 | 9 | 121178 | 0 | 0.02 | 0.969 | ||
drd2_human | 227 | ICL3 | R => C | missense | 8.252e-06 | 1 | 121178 | 0 | 0.0 | 0.982 | ||
drd2_human | 226 | 5.75x75 | TM5 | K => R | missense | 8.25e-06 | 1 | 121212 | 0 | 0.8 | 0.117 | GP (contact) |
drd2_human | 223 | 5.72x72 | TM5 | V => I | missense | 3.298e-05 | 4 | 121290 | 0 | 0.92 | 0.995 | GP (contact) |
drd2_human | 222 | 5.71x71 | TM5 | R => Q | missense | 8.244e-06 | 1 | 121304 | 0 | 0.0 | 1.0 | GP (contact) |
drd2_human | 220 | 5.69x69 | TM5 | R => H | missense | 2.472e-05 | 3 | 121350 | 0 | 0.0 | 0.999 | GP (contact) |
drd2_human | 220 | 5.69x69 | TM5 | R => C | missense | 8.239e-06 | 1 | 121370 | 0 | 0.0 | 0.999 | GP (contact) |
drd2_human | 210 | 5.59x59 | TM5 | I => V | missense | 8.237e-06 | 1 | 121406 | 0 | 1.0 | 0.004 | |
drd2_human | 200 | 5.49x49 | TM5 | V => M | missense | 9.891e-05 | 12 | 121328 | 0 | 0.02 | 0.943 | |
drd2_human | 177 | ECL2 | A => T | missense | 2.673e-05 | 3 | 112252 | 0 | nan | 0.002 | ||
drd2_human | 176 | ECL2 | N => D | missense | 8.807e-06 | 1 | 113550 | 0 | 0.03 | 0.533 | ||
drd2_human | 175 | ECL2 | N => S | missense | 8.765e-06 | 1 | 114088 | 0 | 0.01 | 0.58 | ||
drd2_human | 175 | ECL2 | N => D | missense | 8.749e-06 | 1 | 114296 | 0 | 0.0 | 0.933 | ||
drd2_human | 173 | 4.63x64 | TM4 | G => R | missense | 2.602e-05 | 3 | 115296 | 0 | 0.0 | 1.0 | |
drd2_human | 158 | 4.48x48 | TM4 | I => V | missense | 8.42e-06 | 1 | 118762 | 0 | 1.0 | 0.004 | |
drd2_human | 154 | 4.44x44 | TM4 | V => I | missense | 5.9e-05 | 7 | 118644 | 0 | 0.09 | 0.733 | |
drd2_human | 150 | 4.40x40 | TM4 | R => H | missense | 4.222e-05 | 5 | 118420 | 0 | 0.0 | 0.999 | |
drd2_human | 150 | 4.40x40 | TM4 | R => C | missense | 1.689e-05 | 2 | 118414 | 0 | 0.0 | 0.999 | |
drd2_human | 145 | 4.35x35 | TM4 | R => H | missense | 1.693e-05 | 2 | 118100 | 0 | 0.04 | 1.0 | |
drd2_human | 145 | 4.35x35 | TM4 | R => S | missense | 3.386e-05 | 4 | 118142 | 0 | 0.03 | 1.0 | |
drd2_human | 145 | 4.35x35 | TM4 | R => C | missense | 8.464e-06 | 1 | 118142 | 0 | 0.0 | 1.0 | |
drd2_human | 140 | 34.51x51 | ICL2 | M => V | missense | 8.517e-06 | 1 | 117408 | 0 | 0.6 | 0.986 | GP (contact) |
drd2_human | 138 | 3.56x56 | TM3 | M => V | missense | 8.559e-06 | 1 | 116832 | 0 | 0.0 | 0.997 | GP (contact) |
drd2_human | 134 | 3.52x52 | TM3 | T => I | missense | 8.633e-06 | 1 | 115840 | 0 | 0.14 | 0.999 | PTM (Phosphorylation) |
drd2_human | 131 | 3.49x49 | TM3 | D => N | missense | 1.659e-05 | 2 | 120576 | 0 | 0.0 | 0.871 | SodiumPocket MicroSwitch |
drd2_human | 128 | 3.46x46 | TM3 | I => V | missense | 8.265e-06 | 1 | 120988 | 0 | 0.0 | 0.785 | |
drd2_human | 126 | 3.44x44 | TM3 | C => W | missense | 8.262e-06 | 1 | 121038 | 0 | 0.0 | 1.0 | |
drd2_human | 111 | 3.29x29 | TM3 | V => I | missense | 1.649e-05 | 2 | 121276 | 0 | 0.01 | 0.044 | LB (hydrophobic) |
drd2_human | 99 | 23.49x49 | ECL1 | E => K | missense | 8.262e-06 | 1 | 121036 | 0 | 0.2 | 0.098 | |
drd2_human | 96 | 2.66x65 | TM2 | V => A | missense | 1.656e-05 | 2 | 120746 | 0 | 0.0 | 0.933 | |
drd2_human | 91 | 2.61x60 | TM2 | V => I | missense | 8.451e-06 | 1 | 118330 | 0 | 0.01 | 0.769 | LB (hydrophobic, polar (hydrogen bond)) |
drd2_human | 77 | 2.47x47 | TM2 | A => T | missense | 8.26e-06 | 1 | 121066 | 0 | 0.0 | 1.0 | |
drd2_human | 67 | 2.37x37 | TM2 | T => S | missense | 4.945e-05 | 6 | 121332 | 0 | 0.01 | 0.997 | |
drd2_human | 64 | 12.49x49 | ICL1 | A => V | missense | 0.0001236 | 15 | 121360 | 0 | 0.01 | 0.954 | |
drd2_human | 61 | 1.59x59 | TM1 | R => H | missense | 8.238e-06 | 1 | 121384 | 0 | 0.0 | 1.0 | |
drd2_human | 57 | 1.55x55 | TM1 | M => V | missense | 8.238e-06 | 1 | 121396 | 0 | 0.15 | 0.099 | |
drd2_human | 49 | 1.47x47 | TM1 | V => I | missense | 1.647e-05 | 2 | 121406 | 0 | 0.19 | 0.999 | |
drd2_human | 46 | 1.44x44 | TM1 | A => T | missense | 8.237e-06 | 1 | 121410 | 0 | 0.0 | 0.031 | |
drd2_human | 43 | 1.41x41 | TM1 | L => P | missense | 8.237e-06 | 1 | 121410 | 0 | 0.0 | 1.0 | |
drd2_human | 38 | 1.36x36 | TM1 | A => V | missense | 8.237e-06 | 1 | 121410 | 0 | 0.0 | 0.999 | |
drd2_human | 37 | 1.35x35 | TM1 | Y => C | missense | 1.647e-05 | 2 | 121410 | 0 | 0.0 | 1.0 | |
drd2_human | 29 | N-term | A => V | missense | 4.118e-05 | 5 | 121410 | 0 | 0.28 | 0.016 | ||
drd2_human | 29 | N-term | A => P | missense | 8.237e-06 | 1 | 121410 | 0 | 0.31 | 0.043 | ||
drd2_human | 28 | N-term | K => R | missense | 8.237e-06 | 1 | 121410 | 0 | 0.34 | 0.347 | ||
drd2_human | 27 | N-term | G => R | missense | 1.647e-05 | 2 | 121404 | 0 | 0.26 | 0.075 | ||
drd2_human | 26 | N-term | D => E | missense | 8.237e-06 | 1 | 121408 | 0 | 1.0 | 0.001 | ||
drd2_human | 24 | N-term | G => R | missense | 2.471e-05 | 3 | 121408 | 0 | 0.03 | 0.817 | ||
drd2_human | 20 | N-term | R => Q | missense | 8.237e-06 | 1 | 121410 | 0 | nan | 0.01 | ||
drd2_human | 20 | N-term | R => P | missense | 2.471e-05 | 3 | 121410 | 0 | nan | 0.563 | ||
drd2_human | 20 | N-term | R => W | missense | 3.295e-05 | 4 | 121408 | 0 | nan | 0.785 | ||
drd2_human | 16 | N-term | Q => H | missense | 8.237e-06 | 1 | 121410 | 0 | nan | 0.002 | ||
drd2_human | 10 | N-term | D => H | missense | 1.647e-05 | 2 | 121400 | 0 | 0.01 | 0.531 | ||
drd2_human | 4 | N-term | L => R | missense | 7.414e-05 | 9 | 121394 | 0 | nan | 0.046 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue